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Science 26 February 1965:
Vol. 147. no. 3661, p. 1038
DOI: 10.1126/science.147.3661.1038
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Articles

Cholesterol Biosynthesis: Mevalonate Synthesis Inhibited by Bile Salts

Grace M. Fimognari 1 and Victor W. Rodwell 1

1 Department of Biochemistry, School of Medicine, University of California, San Francisco

Certain bile salts inhibit biosynthesis of mevalonate from acetate-2-C14 in normal rat liver homogenates. The physiological control of cholesterol biosynthesis is discussed.


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