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Science 19 February 1965:
Vol. 147. no. 3660, pp. 887 - 888
DOI: 10.1126/science.147.3660.887
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Articles

5-Hydroxytryptophan Decarboxylase in Rat Brain: Effect of Hypothalamic Lesions

Alfred Heller 1, Lewis S. Seiden 1, William Porcher 1, and Robert Y. Moore 2

1 Department of Pharmacology
2 Departments of Medicine (Neurology) and Anatomy, University of Chicago, Chicago, Illinois

Section of the medial forebrain bundle within the lateral hypothalamus of the rat reduces the serotonin content and the 5-hydroxytryptophan decarboxylase activity in the brain. The integrity of this fiber tract appears necessary for the maintenance of normal concentrations of the amine and enzyme in the telencephalon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Light-Induced Changes in Pineal Hydroxyindole-O-Metthyltransferase: Abolition by Lateral Hypothalamic Lesions.
J. Axelrod, S. H. Snyder, A. Heller, and R. Y. Moore (1966)
Science 154, 898-899
   Abstract »    PDF »
Regional Effects of Hypothalamic Lesions on Brain Serotonin.
R. Y. MOORE, S.-L. R. WONG, and A. HELLER (1965)
Arch Neurol 13, 346-354
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)