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Science 12 February 1965:
Vol. 147. no. 3659, pp. 751 - 753
DOI: 10.1126/science.147.3659.751
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Articles

Immunoassay for Human Chorionic "Growth Hormone-Prolactin" in Serum and Urine

Selna L. Kaplan 1 and Melvin M. Grumbach 1

1 Department of Pediatrics, College of Physicians and Surgeons, Columbia University and Babies Hospital, Presbyterian Hospital, New York, New York

Chorionic "growth hormone-prolactin" in serum and urine from pregnant women, in serum from umbilical cord, and in amniotic fluid was assayed by a sensitive immunological method dependent on the combination of rabbit antiserum to the growth hormone-prolactin with the iodine-131-labeled hormone. The hormone is detectable in serum and urine early in gestation, and with advancing pregnancy its concentration in serum continues to increase to a maximum during the last trimester. It was not found in serum within 8 hours after delivery.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acromegaly and Other Disorders of Growth Hormone Secretion: Combined Clinical Staff Conference at the National Institutes of Health.
J. ROTH, S. M. GLICK, P. CUATRECASAS, and C. S. HOLLANDER (1967)
Ann Intern Med 66, 760-788
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Science. ISSN 0036-8075 (print), 1095-9203 (online)