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Science 12 February 1965:
Vol. 147. no. 3659, pp. 746 - 747
DOI: 10.1126/science.147.3659.746
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Articles

Drug Antagonism between Lincomycin and Erythromycin

L. J. Griffith 1, W. E. Ostrander 1, C. G. Mullins 1, and D. E. Beswick 1

1 Veterans Administration Hospital, Batavia, New York

An antagonistic action can be demonstrated between lincomycin, a new antibiotic, and erythromycin, when the two drugs are allowed to diffuse into the same area of an agar plate seeded with a strain of Staphylococcus which is resistant to erythromycin but sensitive to lincomycin. The increase in the minimum inhibitory concentrations of lincomycin in the presence of erythromycin may be significant in clinical application. The antagonism does not depend on a reaction between the two antibiotics, but appears to be the result of an altered metabolism stimulated by erythromycin on erythromycin-resistant staphylococci.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Streptococcal Pharyngitis: Evaluation of Erythromycin, Erythromycin-Sulfas, and Sulfamethoxazole (Possible Antagonism Between Erythromycin and Sulfas).
W. T. Hughes and R. N. Collier (1969)
Arch Pediatr Adolesc Med 118, 700-707
   Abstract »    PDF »
Lincomycin Versus Erythromycin: A Choice or an Echo.
E. SANDERS (1969)
Ann Intern Med 70, 585-590
   Abstract »    PDF »


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