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Science 5 February 1965:
Vol. 147. no. 3658, pp. 625 - 627
DOI: 10.1126/science.147.3658.625
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Articles

Tumor and Virus Antigens of Simian Virus 40: Differential Inhibition of Synthesis by Cytosine Arabinoside

Fred Rapp 1, Joseph L. Melnick 1, and Tsunehiro Kitahara 1

1 Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

Cells infected with the papovavirus SV40 not only synthesize viral antigen but also synthesize the specific nonviral antigen found in SV40-induced tumors. In the presence of the DNA antagonist cytosine arabinoside, infected cells fail to make viral antigen but still synthesize the tumor antigen. Iododeoxyuridine does not inhibit the synthesis either of tumor or of virus antigen but does prevent the development of infectious virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Adenovirus Infection in Monkey Cells: An Example of Host Restriction at a Step Late in Replication.
S. G. Baum and R. I. Fox (1974)
Cold Spring Harb Symp Quant Biol 39, 567-573
   Abstract »    PDF »
Genetic Phenomena in Experimental Viral Carcinogenesis: Search for Such Phenomena in Cancers of Children.
A. B. SABIN (1966)
Arch Pediatr Adolesc Med 111, 1-10
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)