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Science 22 January 1965:
Vol. 147. no. 3656, pp. 404 - 405
DOI: 10.1126/science.147.3656.404
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Articles

Reovirus Hemagglutination: Inhibition by N-Acetyl-D-glucosamine

Lawrence D. Gelb 1 and A. Martin Lerner 1

1 Departments of Medicine and Microbiology, and Detroit Receiving Hospital, Wayne State University School of Medicine, Detroit, Michigan 48207

Purified reoviruses types 1, 2, and 3 were specifically inhibited in their hemagglutination of human erythrocytes by 250 micromoles or more of N-acetyl-D-glucosamine but not by over 20 other sugars tested. N-acetyl-D-glucosamine inhibited reovirus hemaglutination by binding to capsid virus; it did not attach to the erythrocytes. It is possible that reovirus hemagglutination involves union between N-acetyl-D-glucosamine on the surface of the red cell and the glycoprotein of the virus coat.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)