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Science 25 December 1964:
Vol. 146. no. 3652, pp. 1691 - 1692
DOI: 10.1126/science.146.3652.1691
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Articles

Ethylation: Biological Formation of an S-Ethyl Homolog of Lincomycin

E. L. Patterson 1, J. H. Hash 1, M. Lincks 1, P. A. Miller 1, and N. Bohonos 1

1 Biochemical Research Section, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Streptomyces umbrinus var. cyaneoniger produces the antibiotic lincomycin. When grown in the presence of ethionine an additional antibiotic is produced. Physical and chemical analyses and incorporation of radioisotopes indicate that the new antibiotic is the S-ethyl homolog of lincomycin.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)