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Science 25 December 1964:
Vol. 146. no. 3652, pp. 1678 - 1679
DOI: 10.1126/science.146.3652.1678
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Articles

Hereditary Deficiency of Serum agr1-Antitrypsin

Friedrich Kueppers 1, William A. Briscoe 1, and Alexander G. Bearn 1

1 Rockefeller Institute, and Cardiopulmonary Laboratory, Columbia University Division, Bellevue Hospital, New York

Deficiency of the serum agr1,-antitrypsin appears to be under genetic control. The level of this protein is reduced to less than 10 percent of the norm in individuals homozygous for the trait, who may suffer from pulmonary emphysema. Heterozygous individuals have a concentration of serum agr1-antitrypsin between 50 and 60 percent of normal, but appear to be in good health. The estimated heterozygous frequency of the trait in a small white population in Georgia is 2.1 percent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Introduction.
C. G. Hames (1971)
Arch Intern Med 128, 883-886
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Obstructive Lung Disease in Hereditary {alpha}1-Antitrypsin Deficiency.
R. G. Townley, F. Ryning, H. Lynch, and A. W. Brody (1970)
JAMA 214, 325-331
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Genetic and Environmental Determinants of Chronic Obstructive Pulmonary Disease.
R. K. LARSON, M. L. BARMAN, F. KUEPPERS, and H. H. FUDENBERG (1970)
Ann Intern Med 72, 627-631
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Screening for Homozygous and Heterozygous {alpha}1-Antitrypsin Deficiency: Protein Electrophoresis on Cellulose Acetate Membranes.
J. Lieberman, C. Mittman, and A. S. Schneider (1969)
JAMA 210, 2055-2060
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Obstructive Lung Disease and agr1-Antitrypsin Deficiency Gene Heterozygosity.
F. Kueppers, R. Fallat, and R. K. Larson (1969)
Science 165, 899-901
   Abstract »    PDF »
Inherited Variations of Human Serum agr1-Antitrypsin.
F. Kueppers and A. G. Bearn (1966)
Science 154, 407-408
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