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Science 11 December 1964:
Vol. 146. no. 3650, pp. 1469 - 1470
DOI: 10.1126/science.146.3650.1469
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Articles

Endogenous Pyrogen Release from Rabbit Blood Cells Incubated in vitro with Parainfluenza Virus

Elisha Atkins 1, Muriel Cronin 1, and Peter Isacson 1

1 Department of Internal Medicine and Microbiology, Yale University School of Medicine, New Haven, Connecticut

Rabbit blood cells incubated in vitro with purified parainfluenza-5 virus (DA strain) released a rapidly acting pyrogen. Spleen and lymph node cells were inactive. The pyrogen resembled in behavior a pyrogen extracted from granulocytic exudates. Similar cells in the blood are believed to be activated by virus in vivo to produce the circulating endogenous pyrogen that mediates virus-induced fever.


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