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Science 11 December 1964:
Vol. 146. no. 3650, pp. 1466 - 1469
DOI: 10.1126/science.146.3650.1466
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Articles

Polyoma Virus Genetic Material in a Virus-Free Polyoma-Induce Tumor

David Axelrod 1, Karl Habel 1, and Ellis T. Bolton 2

1 Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, Bethesda 14, Maryland
2 Laboratory of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, D.C.

The DNA-agar technique for homology studies was used to investigate of the viral genetic material. Complemetary found between the polyoma DNA and the DNA of several mammalian species. The increased complementarity of the polyoma DNA to the DNA of polyoma-induced tumor reflects an increased frequency of common poly-nucleotide sequences in the tumor DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polyoma Virus Gene Activity during Lytic Infection and in Transformed Animal Cells.
M. A. Martin and D. Axelrod (1969)
Science 164, 68-70
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Leukemia and Lymphoma.
P. G. Rigby, R. C. Rosenlof, P. T. Pratt, and H. M. Lemon (1966)
JAMA 197, 25-30
   Abstract »    PDF »
Molecular Virology and Cancer.
C. R. Goodheart (1965)
JAMA 194, 48-53
   Abstract »    PDF »


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