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Science 4 December 1964:
Vol. 146. no. 3649, pp. 1328 - 1329
DOI: 10.1126/science.146.3649.1328
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Articles

Paradoxical Phase of Sleep: Its Artificial Induction in the Cat by Sodium Butyrate

M. Matsuzaki 1, H. Takagi 2, and T. Tokizane 3

1 Institute of Brain Research, School of Medicine, University of Tokyo, Tokyo, Japan
2 Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan
3 Institute of Brain Research, School of Medicine, University of Tokyo

In intact cats and cats with the mesencephalon transected the intravenous administration of sodium butyrate and related compounds (0.3 to 3 millimoles per kilogram) induced the so-called paradoxical phase of the sleep, as indicated by electroencephalograms, electromyograms, heart rate, respiration, and eye movement. This phase appeared after a 3- to 5-minute period of sleep characterized by slow waves, and continued for 4 to 15 minutes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sleep: Suppression of Rapid Eye Movement Phase in the Cat after Electroconvulsive Shock.
H. B. Cohen and W. C. Dement (1966)
Science 154, 396-398
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Science. ISSN 0036-8075 (print), 1095-9203 (online)