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Science 4 December 1964:
Vol. 146. no. 3649, pp. 1316 - 1318
DOI: 10.1126/science.146.3649.1316
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Articles

Uricase: Localization in Hepatic Microbodies

Zdenek Hruban 1 and Hewson Swift 2

1 Department of Pathology, University of Chicago, Chicago, Illinois 60637
2 Whitman Laboratory, University of Chicago

Microbodies of rat hepatic cells and hepatomas contain a crystalloid with the same structural characteristics as crystals of purified uricase, when viewed by electron microscopy. We conclude that crystalline uricase is located within hepatic microbodies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Histochem. Cytochem. 47, 1133-1140
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Uric Acid Metabolism in Dalmatians and Other Dogs: Role of the Liver.
G. Kuster, R. G. Shorter, B. Dawson, and G. A. Hallenbeck (1972)
Arch Intern Med 129, 492-496
   Abstract »    PDF »


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