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Science 4 December 1964:
Vol. 146. no. 3649, pp. 1311 - 1313
DOI: 10.1126/science.146.3649.1311
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Articles

Actinomycin D: An Effect on Rat Liver Homogenates Unrelated to Its Action on RNA Synthesis

Michel Revel 1, Howard H. Hiatt 1, and Jean-Paul Revel 2

1 Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts
2 Department of Anatomy, Harvard Medical School

Liver homogenates prepared from rats injected with high doses of actinomycin D show a decrease in polyribosome content and in amino acid incorporation. These effects are not observed in rat liver not subjected to homogenization and are independent of the inhibition of RNA synthesis caused by the antibiotic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metabolic Aspects of Acid-Base Change.
W. D. Lotspeich (1967)
Science 155, 1066-1075
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Actinomycin D: Inhibition of Respiration and Glycolysis.
J. Laszlo, D. S. Miller, K. S. McCarty, and P. Hochstein (1966)
Science 151, 1007-1010
   Abstract »    PDF »
Effect of Gamma Radiation on Dietary and Hormonal Induction of Enzymes in Rat Liver.
H. C. Pitot, C. Peraino, C. Lamar Jr., and S. Lesher (1965)
Science 150, 901-903
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Actinomycin D: Inhibition of Protein Synthesis Unrelated to Effect on Template RNA Synthesis.
G. R. Honig and M. Rabinovitz (1965)
Science 149, 1504-1506
   Abstract »    PDF »
Functional Ribosomal Unit of Gamma-Globulin Synthesis.
M. D. Scharff and J. W. Uhr (1965)
Science 148, 646-648
   Abstract »    PDF »


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