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Science 4 December 1964:
Vol. 146. no. 3649, pp. 1300 - 1305
DOI: 10.1126/science.146.3649.1300
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Articles

Thalidomide Syndrome in Monkeys

C. S. Delahunt 1 and L. J. Lassen 1

1 Pharmacology Department, Chas. Pfizer & Co., Groton, Connecticut

Pregnant monkeys were treated with thalidomide after implantation but before formation of the fetal limbs. Two fetuses that were recovered from the treated females had congenital abnormalities. The thalidomide syndrome in the monkeys was manifested by amelia, phocomelia, internal hydrocephaly, facial capillary hemangioma, hypogenesis of the metatarsal bones, and anotia.


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