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Science 27 November 1964:
Vol. 146. no. 3648, pp. 1166 - 1168
DOI: 10.1126/science.146.3648.1166
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Articles

Insulin Action in Alloxan Diabetes Modified by Actinomycin D

Alfred Gellhorn 1 and William Benjamin 1

1 Chester Beatty Research Institute, Institute of Cancer Research, and Royal Cancer Hospital, Fulham Road, London, S.W.3

Insulin corrects the disturbances in lipid and carbohydrate metabolism in rats made diabetic with alloxan. However, the concomitant administration of actinomycin D with insulin prevents the repair of enzymatic defects in the syntheses of total fatty acids by adipose tissue, of monounsaturated fatty acids by liver microsomes, and of hepatic glycogen. The hypoglycemic action of insulin in diabetes is not modified by actinomycin injections. These findings indicate that a fundamental mechanism of action of insulin is the induction of enzyme synthesis through stimulating the renewal of cellular RNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.
J. M. Ntambi (1999)
J. Lipid Res. 40, 1549-1558
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Science. ISSN 0036-8075 (print), 1095-9203 (online)