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Science 6 November 1964:
Vol. 146. no. 3645, pp. 772 - 774
DOI: 10.1126/science.146.3645.772
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Articles

Streptomycinoid Antibiotics: Synergism by Puromycin

James R. White 1 and Helen Lyng White 1

1 Department of Biochemistry and Nutrition, Medical School, University of North Carolina, Chapel Hill

Puromycin synergizes the lethal action of streptomycin and related antibiotics. This is interpreted to mean that puromycin action uncovers a sensitive site (or sites) on the 30S ribosome. The streptomycinoid antibiotics can then associate more readily with the ribosome and inhibit further synthesis of valid protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Treatment of Gram-Negative Bacillary Meningitis in Adults.
J. J. RAHAL JR. (1972)
Ann Intern Med 77, 295-302
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Science. ISSN 0036-8075 (print), 1095-9203 (online)