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Science 6 November 1964:
Vol. 146. no. 3645, pp. 766 - 768
DOI: 10.1126/science.146.3645.766
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Articles

Protein Synthesis Enhanced in the Liver of Rats Force-Fed a Threonine-Devoid Diet

Herschel Sidransky 1, Theophil Staehelin 1, and Ethel Verney 1

1 Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213

There is enhanced incorporation of leucine-C14 into proteins in cell-free preparations from livers of young rats force-fed a threonine-devoid diet for 3 days. This increased protein synthesis in the liver is related predominantly to enhanced activity of ribosomes. The aggregates of liver ribosomes (ergosonmes or polysomes) as measured in a sucrose gradient indicated a shift from lighter toward heavier ergosomes with a decrease in monomers.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)