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Science 25 September 1964:
Vol. 145. no. 3639, pp. 1443 - 1444
DOI: 10.1126/science.145.3639.1443
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Articles

Rubella Virus: Inhibition in vitro by Amantadine Hydrochloride

Hunein F. Maassab 1 and Kenneth W. Cochran 1

1 Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor

Amantadine (or 1-adamantanamine) hydrochloride, a compound reported to be active against influenza viruses and Sendai virus, inhibited the growth of rubella virus in tissue culture. The antiviral activity appears at an early phase of the infection and is not due to direct inactivation of the virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of Amantadine Hydrochloride on the Response of Human Lymphocytes to Phytohemagglutinin.
W. E. Rawls, J. L. Melnick, G. B. Olson, P. B. Dent, and R. A. Good (1967)
Science 158, 506-507
   Abstract »    PDF »
Amantadine Hydrochloride: Analysis of Data Related to Its Proposed Use for Prevention of A2 Influenza Virus Disease in Human Beings.
A. B. Sabin (1967)
JAMA 200, 943-950
   Abstract »    PDF »
1-Adamantanamine Hydrochloride: Inhibition of Rous and Esh Sarcoma Viruses in Cell Culture.
A. M. Wallbank, R. E. Matter, and N. G. Klinikowski (1966)
Science 152, 1760-1761
   Abstract »    PDF »


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