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Science 25 September 1964:
Vol. 145. no. 3639, pp. 1439 - 1441
DOI: 10.1126/science.145.3639.1439-a
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Articles

Reduction of Cardiac Stores of Norepinephrine in Experimental Heart Failure

James F. Spann Jr. 1, Charles A. Chidsey 1, and Eugene Braunwald 1

1 Cardiology Branch, National Heart Institute, Bethesda, Maryland 20014

Constriction of the ascending aorta in the guinea pig resulted in ventricular hypertrophy and congestive heart failure. In animals with heart failure which were killed 5 to 40 days after constriction, the norepinephrine stores in both ventricles were strikingly reduced; the extent of reduction was related to the severity of the constriction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diastolic Properties of the Left Ventricle.
W. GROSSMAN and L. P. McLAURIN (1976)
Ann Intern Med 84, 316-326
   Abstract »    PDF »
Hypertension and the Heart.
J. N. Cohn, C. J. Limas, and N. H. Guiha (1974)
Arch Intern Med 133, 969-979
   Abstract »    PDF »
Congestive Heart Failure: Biochemical and Physiological Considerations * Combined Clinical Staff Conference at the National Institutes of Health.
E. BRAUNWALD, C. A. CHIDSEY, P. E. POOL, E. H. SONNENBLICK, J. ROSS JR., D. T. MASON, J. F. SPANN, and J. W. COVELL (1966)
Ann Intern Med 64, 904-941
   Abstract »    PDF »


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