Irreparable Mutations and Ethionine Resistance in Neurospora
Robert L. Metzenberg 1,
Michael S. Kappy 1, and
Judith W. Parson 1
1 Department of Physiological Chemistry, University of Wisconsin Medical School, Madison
Some ethionine-resistant mutants of Neurospora crassa are temperature-sensitive,in that they fail to grow in the upper temperature range at which wild type Neurospora grow best. Two of these mutants have lost an indispensable function since at elevated temperatures they are unable to grow on a variety of complex media.