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Science 25 September 1964:
Vol. 145. no. 3639, pp. 1429 - 1430
DOI: 10.1126/science.145.3639.1429
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Articles

Fetal Death from Nicotinamide-Deficient Diet and Its Prevention by Chlorpromazine and Imipramine

Italo Fratta 1, Sylvia B. Zak 1, Paul Greengard 1, and Ernest B. Sigg 1

1 Geigy Research Laboratories, Ardsley, New York

Feeding a diet deficient in nicotinamide, nicotinic acid, and tryptophan to pregnant rats causes death and resorption of all fetuses. This effect can be prevented by administration of either chlorpromazine or imipramine. Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide.
L. M.J.W. van Driel, H. P.M. Smedts, W. A. Helbing, A. Isaacs, J. Lindemans, A. G. Uitterlinden, C. M. van Duijn, J. H.M. de Vries, E. A.P. Steegers, and R. P.M. Steegers-Theunissen (2008)
Eur. Heart J. 29, 1424-1431
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Science. ISSN 0036-8075 (print), 1095-9203 (online)