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Science 25 September 1964:
Vol. 145. no. 3639, pp. 1427 - 1429
DOI: 10.1126/science.145.3639.1427
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Articles

Homograft Target Cells: Specific Destruction in vitro by Contact Interaction with Immune Macrophages

Gale A. Granger 1 and Russell S. Weiser 1

1 Department of Microbiology, University of Washington School of Medicine, Seattle

Specific adherence and mutual immunologic destruction occurred after contact in vitro of immune peritoneal macrophages from C57BI/6K mice with homograft target cells from A/Jax mice. Cell destruction apparently resulted from a nonphagocytic mechanism involving cell contact rather than humoral antibody. Cell destruction was determined by a plaque technique with either immunecells or target cells as monolayers.


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