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Science 18 September 1964:
Vol. 145. no. 3638, pp. 1315 - 1316
DOI: 10.1126/science.145.3638.1315
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Articles

Genetic Studies on the Mixed Leukocyte Reaction

Barbara Bain 1 and Louis Lowenstein 1

1 Division of Hematology, Royal Victoria Hospital, Montreal, Canada

When leukocytes from pairs of unrelated human subjects are mixed and cultured for several days, blast-like cells appear that are capable of DNA synthesis and mitosis. This reaction can be estimated quantitatively by measuring the uptake of tritiated thymidine in the cultures. In experiments with 15 sibling pairs, the leukocytes of most individuals reacted less strongly with those of their siblings than with those of an unrelated subject.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mixed Leukocyte Reactions and Histocompatibility in Rats.
W. K. Silvers, D. B. Wilson, and J. Palm (1967)
Science 155, 703-704
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One-Way Stimulation in Mixed Leukocyte Cultures.
F. H. Bach and N. K. Voynow (1966)
Science 153, 545-547
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Progress in the Determination of Histocompatibility.
J. W. Streilein, R. E. Billingham, and W. K. Silvers (1966)
JAMA 195, 351-355
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Renal Homotransplantation Using Cadaver Donors.
L. D. MacLEAN, J. B. DOSSETOR, M. H. GAULT, J. A. OLIVER, F. G. INGLIS, and K. J. MacKINNON (1965)
Arch Surg 91, 288-306
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