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Science 11 September 1964:
Vol. 145. no. 3637, pp. 1197 - 1199
DOI: 10.1126/science.145.3637.1197
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Articles

Inhibition of Specific Binding of Antibody to the Rh0(D) Factor of Red Cells in Antibody Excess

S. P. Masouredis 1, Mary Edith Dupuy 1, and Margaret Elliot 1

1 Department of Medicine and Cancer Research Institute, University of California, San Francisco

The uptake by red cells of I131-labeled nonagglutinating antibody to the Rh0(D) factor was dependent on the proportion of cells to antibody during sensitization. Inhibition of antibody binding by red cells in the region of antibody excess occurred with Rh0(D) positive red cells that were both papain modified and untreated; the inhibition was independent of the Rh phenotype.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)