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Science 11 September 1964:
Vol. 145. no. 3637, pp. 1190 - 1192
DOI: 10.1126/science.145.3637.1190
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Articles

Adenovirus-like Particles from Cancers Induced by Adenovirus-12 but Free of Infectious Virus

Kendall O. Smith 1 and Joseph L. Melnick 1

1 Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

Particles resembling adenovirus were recovered from tumors induced by adenovirus-12. The particles were similar to incomplete adenovirus in size, subunit morphology, and density. The presence of such incomplete viral units helps to explain why attempts to isolate infectious virus from adenovirus-induced tumors have failed despite the serological evidence that viral elements are present.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viral Hemorrhagic Encephalopathy of Rats.
A. H. ElDadah, N. Nathanson, K. O. Smith, R. A. Squire, G. W. Santos, and E. C. Melby (1967)
Science 156, 392-394
   Abstract »    PDF »
Genetic Phenomena in Experimental Viral Carcinogenesis: Search for Such Phenomena in Cancers of Children.
A. B. SABIN (1966)
Arch Pediatr Adolesc Med 111, 1-10
   Abstract »    PDF »
Adenovirus-Associated Defective Virus Particles.
R. W. Atchison, B. C. Casto, and W. McD. Hammon (1965)
Science 149, 754-755
   Abstract »    PDF »
Cyclic Structure of Adenovirus DNA.
K. O. Smith (1965)
Science 148, 100-102
   Abstract »    PDF »


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