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Science 21 August 1964:
Vol. 145. no. 3634, pp. 828 - 829
DOI: 10.1126/science.145.3634.828
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Articles

Release of Metaraminol (Aramine) from the Heart by Sympathetic Nerve Stimulation

J. R. Crout 1, H. S. Alpers 1, E. L. Tatum 1, and P. A. Shore 1

1 Departments of Pharmacology and Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235

Cats were injected intravenously with metaraminol, an amine which depletes norepinephrine from the sympathetic nerve endings; their hearts were then perfused in vitro. Stimulation of the sympathetic nerve supply released metaraminol from the hearts, demonstrating that a synthetic compound can replace norepinephrine and serve as a transmitter at adrenergic nerve endings


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