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Science 21 August 1964:
Vol. 145. no. 3634, pp. 826 - 827
DOI: 10.1126/science.145.3634.826
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Articles

Uric Acid Transport System: Apparent Absence in Erythrocytes of the Dalmatian Coach Hound

Alice M. Harvey 1 and Halvor N. Christensen 1

1 Department of Biological Chemistry, University of Michigan, Ann Arbor

The Dalmatian coach hound appears to lack a mediated transport system for uric acid, which can be demonstrated in the erythrocytes of other dogs by hypoxanthine inhibition of uric acid uptake. This transport deficiency may be a manifestation of a genetic defect which has different metabolic consequences in the liver, in the kidney, and in other tissues, depending on the direction of their differentiation


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Uric Acid Metabolism in Dalmatians and Other Dogs: Role of the Liver.
G. Kuster, R. G. Shorter, B. Dawson, and G. A. Hallenbeck (1972)
Arch Intern Med 129, 492-496
   Abstract »    PDF »
Renal Allotransplantation and Allantoin Excretion of Dalmatian.
R. COHN, D. G. DIBBELL, D. R. LAUB, and S. L. KOUNTZ (1965)
Arch Surg 91, 911-912
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)