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Science 21 August 1964:
Vol. 145. no. 3634, pp. 811 - 813
DOI: 10.1126/science.145.3634.811-a
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Articles

Purified Interferons: Physical Properties and Species Specificity

Thomas C. Merigan 1

1 Department of Medicine, Stanford University School of Medicine, and Palo Alto Veterans Administration Hospital, Palo Alto, California

The antiviral activity of highly purified preparations of chick and mouse interferons has marked species specificity. This species specificity is not explained by a demonstrable difference in adsorption rates. There is no difference in charge between the molecules as measured by combined zone electrophoresis or ion-exchange chromatography. The interferons are distinguishable by thermal inactivation studies and by precise chromatography on G-100 Sephadex columns. With the latter method, interferons produced by the same cell species (i) in vivo or in vitro, or (ii) in response to different viruses, have been shown to be identical. The same virus stimulates physically distinguishable molecules in the two different cell species. These findings indicate that interferon is a virus-induced product of the host genome


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanism of Action of Interferon.
R. M. Friedman and J. A. Sonnabend (1970)
Arch Intern Med 126, 51-63
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