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Science 7 August 1964:
Vol. 145. no. 3632, pp. 606 - 607
DOI: 10.1126/science.145.3632.606
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Articles

Oxidation of Extramitochondrial Diphosphopyridine Nucleotide by Various Tissues of the Mouse

Bertram Sacktor 1 and Arthur R. Dick 1

1 Chemical Research and Development Laboratories, U.S. Army Edgewood Arsenal, Maryland 21010

Exogenous reduced diphosphopyridine nucleotide was not oxidized by mitochondria but by cytoplasmic hydrogen-accepting systems catalyzed by lactic, agr-glycerophosphate, and malic dehydrogenases. The three enzymes were found in all tissues of the mouse; the amount of activity of each enzyme differed in the various tissues, however. It is suggested that each tissue has a unique pattern for oxidation of extramitochondrial diphosphopyridine nucleotide.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)