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Science 31 July 1964:
Vol. 145. no. 3631, pp. 501 - 503
DOI: 10.1126/science.145.3631.501
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Articles

Polydactylism in the Offspring of Mice Injected with 5-Bromodeoxyuridine

Joseph A. Dipaolo 1

1 Cytogenetics and Cytology Unit, National Cancer Institute, Bethesda, Maryland 20014

The intraperitoneal injection of multiple doses of 5-bromodeoxyuridine (BUDR) into pregnant mice produced abnormalities limited to the hind limbs of the offspring. This effect is probably a result of a metabolic lesion. When injected into newborn mice, BUDR did not increase the incidence of tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Embryonic and Postnatal Injections of Bromodeoxyuridine Produce Age-Dependent Morphological and Behavioral Abnormalities.
B. Kolb, B. Pedersen, M. Ballermann, R. Gibb, and I. Q. Whishaw (1999)
J. Neurosci. 19, 2337-2346
   Abstract »    Full Text »    PDF »
Cerebral Lateralization: Biological Mechanisms, Associations, and Pathology: II. A Hypothesis and a Program for Research.
N. Geschwind and A. M. Galaburda (1985)
Arch Neurol 42, 521-552
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)