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Science 31 July 1964:
Vol. 145. no. 3631, pp. 491 - 492
DOI: 10.1126/science.145.3631.491
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Articles

Tryptophan Synthetase from Neurospora: A Modification in the Reaction Scheme

Michael D. Garrick 1, Harrold Elberfeld 2, and Sigmund R. Suskind 3

1 Moore Clinic, Johns Hopkins Hospital, Baltimore, Maryland
2 Basic Sciences Building, Johns Hopkins Medical School
3 McCollum-Pratt Institute, Johns Hopkins University

In addition to indole-3-glycerolphosphate, an unreported reaction product has been detected in incubation mixtures containing tryptophan synthetase from Neurospora, indole, and glyceraldehyde-3-phosphate. This product has been tentatively identified as an indole derivative. Since this compound is not formed in incubation mixtures initially containing only enzyme and indole-3-glycerolphosphate, it was concluded that indole-3-glycerolphosphate synthesis and breakdown are not simply the forward and reverse components of a reversible reaction.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)