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Science 24 July 1964:
Vol. 145. no. 3630, pp. 397 - 399
DOI: 10.1126/science.145.3630.397
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Articles

Alkylation of Synthetic Polynucleotides

David B. Ludlum 1, Robert C. Warner 1, and Albert J. Wahba 1

1 Department of Biochemistry, New York University School of Medicine, New York 10016

The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single-Stranded DNA as a Template for in Vitro Protein Synthesis.
B. J. McCarthy, J. J. Holland, and C. A. Buck (1966)
Cold Spring Harb Symp Quant Biol 31, 683-691
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Science. ISSN 0036-8075 (print), 1095-9203 (online)