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Science 3 July 1964:
Vol. 145. no. 3627, pp. 58 - 60
DOI: 10.1126/science.145.3627.58
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Articles

Pyruvate Metabolism and Control: Factors Affecting Pyruvic Carboxylase Activity

Aaron D. Freedman 1 and Leonard Kohn 1

1 Departments of Biochemistry and Medicine, College of Physicians and Surgeons, Columbia University, New York

Pyruvic carboxylase activated by acetyl coenzyme A is highly active in the mitochondria of rodent liver, and its activity is increased in fasting and alloxan diabetes. In conjunction with acyl carboxylase activated by di- and tricarboxylic acid, it forms a reciprocating control network. Analog models of similar networks tend to correct for perturbations, stabilizing the overall system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Feedback Inhibition of Key Glycolytic Enzymes in Liver: Action of Free Fatty Acids.
G. Weber, H. J. H. Convery, M. A. Lea, and N. B. Stamm (1966)
Science 154, 1357-1360
   Abstract »    PDF »
Insulin: Inducer of Pyruvate Kinase.
G. Weber, N. B. Stamm, and E. A. Fisher (1965)
Science 149, 65-67
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)