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Science 26 June 1964:
Vol. 144. no. 3626, p. 1584
DOI: 10.1126/science.144.3626.1584
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Articles

Complement-Fixing Antigens in Tissue Cultures of Avian Leucosis Viruses

Donald Armstrong 1, Melahat Okuyan 1, and Robert J. Huebner 1

1 National Institute of Allergy and Infectious Diseases and National Cancer Institute, Bethesda, Maryland

Avian sarcoma and leucosis virus preparations grown in chick embryo tissue cultures contained complement-fixing antigens, which were demonstrated with the use of antiserums from hamsters carrying sarcomas induced by the Schmidt-Ruppin strain of avian sarcoma virus. The complement-fixing antigens shared by three different strains of avian leucosis and one strain of avian sarcoma viruses were largely "soluble" (having failed to sediment when centrifuged at 59,364g for 70 minutes). Sedimented particles, presumably virus particles, contained the common sarcoma-leucosis antigen as well.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rous Sarcoma Virus Nucleotide Sequences in Cellular DNA: Measurement by RNA-DNA Hybridization.
P. E. Neiman (1972)
Science 178, 750-753
   Abstract »    PDF »
Complement-Fixing Antigens in Hamster Tumors Induced by the Bryan Strain of Rous Sarcoma Virus.
M. J. Casey, G. F. Rabotti, P. S. Sarma, W. T. Lane, H. C. Turner, and R. J. Huebner (1966)
Science 151, 1086-1088
   Abstract »    PDF »


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