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Science 5 June 1964:
Vol. 144. no. 3623, pp. 1223 - 1225
DOI: 10.1126/science.144.3623.1223
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Articles

Negative Inotropic Effect of the Vagus Nerves upon the Canine Ventricle

Hilaire DeGeest 1, Matthew N. Levy 1, and Harrison Zieske 1

1 Research Division, St. Vincent Charity Hospital, Cleveland, Ohio

In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the teft ventricle. The vagi, therefore, exert a negative inotropic effect directly upon the ventricular myocardium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transient Atrioventricular Standstill: Etiology and Management.
P. K. Gupta, E. Lichstein, and K. D. Chadda (1975)
JAMA 234, 1038-1042
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Science. ISSN 0036-8075 (print), 1095-9203 (online)