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Science 29 May 1964:
Vol. 144. no. 3622, pp. 1135 - 1137
DOI: 10.1126/science.144.3622.1135
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Articles

Serotonin Binding to Nerve-Ending Particles of the Rat Brain and Its Inhibition by Lysergic Acid Diethylamide

R. M. Marchbanks 1, Frank Rosenblatt 1, and Richard D. O'Brien 1

1 Cognitive Systems Research Program and Department of Entomology, Cornell University, Ithaca, New York

The binding of serotonin to nerve-ending particles and other preparations from rat brain has been examined. By investigating the amount bound as a function of serotonin concentration from 10-7M to 1O-2M, it was possible to identify three major components having Kassoc (association constant) values of 2 x 106, 5 x 104, and 5 x 102. The component having the highest binding constant was not present in liver and appeared to be confined to the cortex and midbrain regions. This component is inhibited by d-lysergic acid diethylamide at low concentrations. Solubilization of this binding component has been achieved.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Receptors: Localization and Specificity of Binding of Serotonin in the Central Nervous System.
S. G. A. Alivisatos, F. Ungar, P. K. Seth, L. P. Levitt, A. J. Geroulis, and T. S. Meyer (1971)
Science 171, 809-812
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Science. ISSN 0036-8075 (print), 1095-9203 (online)