Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 May 1964:
Vol. 144. no. 3620, pp. 862 - 863
DOI: 10.1126/science.144.3620.862
Prev | Table of Contents | Next

Articles

Antiviral Activity of 1-Adamantanamine (Amantadine)

W. L. Davies 1, R. R. Grunert 1, R. F. Haff 1, J. W. McGahen 1, E. M. Neumayer 1, M. Paulshock 1, J. C. Watts 1, T. R. Wood 1, E. C. Hermann 1, and C. E. Hoffmann 1

1 Pharmaceutical Research Division, Industrial and Biochemicals Department, E. I. du Pont de Nemours and Company, Wilmington, Delaware

I-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition of influenza infections in tissue culture, chick embryos, and mice. The compound is not virucidal and appears to act by interfering with the penetration of the host cell by the virus. In influenza infections of mice, greatest efficacy occurs with treatment at the time of infection; however, there is significant antiviral activity with treatment delayed up to 72 hours after infection. Virus inhibition is not complete and survivors are immune to a challenge infection with the original infecting virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition.
Y. Ohigashi, C. Ma, X. Jing, V. Balannick, L. H. Pinto, and R. A. Lamb (2009)
PNAS 106, 18775-18779
   Abstract »    Full Text »    PDF »
Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation.
A. C. Hurt, J. K. Holien, M. Parker, A. Kelso, and I. G. Barr (2009)
J. Virol. 83, 10366-10373
   Abstract »    Full Text »    PDF »
Identification of the Pore-lining Residues of the BM2 Ion Channel Protein of Influenza B Virus.
C. Ma, C. S. Soto, Y. Ohigashi, A. Taylor, V. Bournas, B. Glawe, M. K. Udo, W. F. DeGrado, R. A. Lamb, and L. H. Pinto (2008)
J. Biol. Chem. 283, 15921-15931
   Abstract »    Full Text »    PDF »
The M2 Proton Channels of Influenza A and B Viruses.
L. H. Pinto and R. A. Lamb (2006)
J. Biol. Chem. 281, 8997-9000
   Full Text »    PDF »
Amantadine Inhibits NMDA Receptors by Accelerating Channel Closure during Channel Block.
T. A. Blanpied, R. J. Clarke, and J. W. Johnson (2005)
J. Neurosci. 25, 3312-3322
   Abstract »    Full Text »    PDF »
Voltage-Gated Proton Channels and Other Proton Transfer Pathways.
T. E. Decoursey (2003)
Physiol Rev 83, 475-579
   Abstract »    Full Text »    PDF »
Oral Administration of Cyclopentane Neuraminidase Inhibitors Protects Ferrets against Influenza Virus Infection.
C. Sweet, K. J. Jakeman, K. Bush, P. C. Wagaman, L. A. Mckown, A. J. Streeter, D. Desai-Krieger, P. Chand, and Y. S. Babu (2002)
Antimicrob. Agents Chemother. 46, 996-1004
   Abstract »    Full Text »    PDF »
Amantadine Inhibits Nicotinic Acetylcholine Receptor Function in Hippocampal Neurons.
H. Matsubayashi, K. L. Swanson, and E. X. Albuquerque (1997)
J. Pharmacol. Exp. Ther. 281, 834-844
   Abstract »    Full Text »
Present status and future prospects for HIV therapies.
M. Johnston and D. Hoth (1993)
Science 260, 1286-1293
   Abstract »    PDF »
Reversible Pathologic Jealousy (Othello Syndrome) Associated With Amantadine.
P. McNamara and R. Durso (1991)
J Geriatr Psychiatry Neurol 4, 157-159
   Abstract »    PDF »
Antiviral Drugs in Pediatrics.
H. H. Balfour Jr and J. A. Englund (1989)
Arch Pediatr Adolesc Med 143, 1307-1316
   Abstract »    PDF »
Sculpting horizons in organic chemistry.
B. Trost (1985)
Science 227, 908-916
   Abstract »    PDF »
The Effect of Amantadine on Arousal and EEG Patterns in Creutzfeldt-Jakob Disease.
M. G. Terzano, E. Montanari, S. Calzetti, D. Mancia, and A. Lechi (1983)
Arch Neurol 40, 555-559
   Abstract »    PDF »
Prevention of Russian Influenza by Amantadine.
A. S. Monto, R. A. Gunn, M. G. Bandyk, and C. L. King (1979)
JAMA 241, 1003-1007
   Abstract »    PDF »
Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor.
E. Albuquerque, A. Eldefrawi, M. Eldefrawi, N. Mansour, and M. Tsai (1978)
Science 199, 788-790
   Abstract »    PDF »
Prevention and Control of Influenza by Chemoprophylaxis and Chemotherapy: Prospects From Examination of Recent Experience.
G. G. Jackson and E. D. Stanley (1976)
JAMA 235, 2739-2742
   Abstract »    PDF »
Evaluation of Amantadine in Artificially Induced A2 and B Influenza.
A. A. Smorodintsev, D. M. Zlydnikov, A. M. Kiseleva, J. A. Romanov, A. P. Kazantsev, and V. I. Rumovsky (1970)
JAMA 213, 1448-1454
   Abstract »    PDF »
Amantadine-Dopamine Interaction: Possible Mode of Action in Parkinsonism.
R. P. Grelak, R. Clark, J. M. Stump, and V. G. Vernier (1970)
Science 169, 203-204
   Abstract »    PDF »
Evaluation of Therapeutic Efficacy of Amantadine in Patients With Naturally Occurring A2 Influenza.
Y. Togo, R. B. Hornick, V. J. Felitti, M. L. Kaufman, A. T. Dawkins Jr., V. E. Kilpe, and J. L. Claghorn (1970)
JAMA 211, 1149-1156
   Abstract »    PDF »
Studies on Induced Influenza in Man: I. Double-Blind Studies Designed to Assess Prophylactic Efficacy of Amantadine Hydrochloride Against A2/Rockville/1/65 Strain.
Y. Togo, R. B. Hornick, and A. T. Dawkins Jr. (1968)
JAMA 203, 1089-1094
   Abstract »    PDF »
Effect of Amantadine Hydrochloride on the Response of Human Lymphocytes to Phytohemagglutinin.
W. E. Rawls, J. L. Melnick, G. B. Olson, P. B. Dent, and R. A. Good (1967)
Science 158, 506-507
   Abstract »    PDF »
Amantadine Hydrochloride: Analysis of Data Related to Its Proposed Use for Prevention of A2 Influenza Virus Disease in Human Beings.
A. B. Sabin (1967)
JAMA 200, 943-950
   Abstract »    PDF »
1-Adamantanamine Hydrochloride: Inhibition of Rous and Esh Sarcoma Viruses in Cell Culture.
A. M. Wallbank, R. E. Matter, and N. G. Klinikowski (1966)
Science 152, 1760-1761
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)