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Science 15 May 1964:
Vol. 144. no. 3620, pp. 844 - 846
DOI: 10.1126/science.144.3620.844
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Articles

Spleen-Colony Formation in Anemic Mice of Genotype WW

E. A. McCulloch 1, L. Siminovitch 1, and J. E. Till 1

1 Department of Medical Biophysics, University of Toronto, and Ontario Cancer Institute, Toronto, Canada

The hemopoietic cells from anemic mice of genotype WW are less able by 200-fold to take part in colony formationin the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice formcolonies in the spleens of unirradiated mice of genotype WW. Use of animals of genotype WVVWT as recipients improves the spleen-colony method by removing bias resulting fromthe death of irradiated recipients.


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