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Science 1 May 1964:
Vol. 144. no. 3618, pp. 552 - 553
DOI: 10.1126/science.144.3618.552
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Articles

Hemoglobins A and F: Formation in Thalassemia and Other Hemolytic Anemias

Paul A. Marks 1 and Edward R. Burka 1

1 Columbia University College of Physicians and Surgeons, New York, New York

Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Heme and Globin Synthesis Control: Observations in vivo in Beta Thalassemia.
M. Kreimer-Birnbaum and R. M. Bannerman (1967)
Science 155, 1116-1118
   Abstract »    PDF »
Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia.
E. H. Eylar and G. T. Matioli (1965)
Science 147, 869-870
   Abstract »    PDF »
Compensatory Effects in the Synthesis of Hemoglobin Polypeptide Chains.
E. Zuckerkandl (1964)
Cold Spring Harb Symp Quant Biol 29, 357-374
   Abstract »    PDF »
Current Concepts of the Genetics of the Thalassemias.
A. G. Motulsky (1964)
Cold Spring Harb Symp Quant Biol 29, 399-413
   Abstract »    PDF »


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