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Science 1 May 1964:
Vol. 144. no. 3618, pp. 539 - 540
DOI: 10.1126/science.144.3618.539
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Articles

Nicotinic Acid Analogs: Effects on Response of Chick Embryos and Hens to Organophosphate Toxicants

J-C. Roger 1, H. Chambers 1, and J. E. Casida 1

1 Department of Entomology, University of Wisconsin, Madison 6

Embryonic abnormalities are known to be induced in chick embryos when they are injected with certain organophosphate insecticides prior to incubation. The marked teratogenic effects of Bidrin [3-(dimethoxyphosphinyloxy) N, N-dimethyl-cis-crotonamide] can be alleviated by many analogs of nicotinamide and nicotinamide adenine dinucleotide. Successive hydroxylation and N-dealkylation of Bidrin in the egg are not greatly altered by injection of nicotinamide. The delayed neurotoxicity in adult hens after administering tri-o-cresyl phosphate is also partially relieved by administering certain nicotinamide analogs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Organophosphorus and methyl carbamate insecticide teratogenesis: diminished NAD in chicken embryos.
N. Proctor and J. Casida (1975)
Science 190, 580-582
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