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Science 17 April 1964:
Vol. 144. no. 3616, pp. 298 - 301
DOI: 10.1126/science.144.3616.298
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Articles

Cytological Evidence for Crossing-Over in vitro in Human Lymphoid Cells

James German 1

1 Rockefeller Institute, New York 21

In human blood cells dividing in vitro two chromosomes are occasionally found intimately associated in a quadriradial configuration (Qr). A Qr by traditional interpretation is the result of chromatid interchange. Since the configurations in blood cells often are equal and symmetrical and are composed of homologous chromosomes, they are considered cytological evidence that somatic crossing-over may occur in mammalian cells.


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