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Science 3 April 1964:
Vol. 144. no. 3614, pp. 67 - 68
DOI: 10.1126/science.144.3614.67
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Articles

Alpha-Ketoglutaric Semialdehyde: A Metabolic Intermediate

Raizada M. M. Singh 1 and Elijah Adams 1

1 Department of Biological Chemistry, University of Maryland School of Medicine, Baltimore

agr-Ketoglutaric semialdehyde has been obtained as a product of hydroxyproline through reactions catalyzed by purified enzymes from Pseudomonas. It has been characterized both by chemical and enzymatic derivatives and by comparison with the chemically synthesized compound. This reactive compound, not previously known as a product of biological reactions, may participate in other metabolic pathways.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}-Ketoglutaric Semialdehyde Dehydrogenase Isozymes Involved in Metabolic Pathways of D-Glucarate, D-Galactarate, and Hydroxy-L-proline: MOLECULAR AND METABOLIC CONVERGENT EVOLUTION.
S. Watanabe, M. Yamada, I. Ohtsu, and K. Makino (2007)
J. Biol. Chem. 282, 6685-6695
   Abstract »    Full Text »    PDF »
A Novel {alpha}-Ketoglutaric Semialdehyde Dehydrogenase: EVOLUTIONARY INSIGHT INTO AN ALTERNATIVE PATHWAY OF BACTERIAL L-ARABINOSE METABOLISM.
S. Watanabe, T. Kodaki, and K. Makino (2006)
J. Biol. Chem. 281, 28876-28888
   Abstract »    Full Text »    PDF »
Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism: Biochemistry and Clinical Applications.
D. J. PROCKOP and K. I. KIVIRIKKO (1967)
Ann Intern Med 66, 1243-1266
   Abstract »    PDF »


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