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Science 20 March 1964:
Vol. 143. no. 3612, pp. 1333 - 1334
DOI: 10.1126/science.143.3612.1333
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Articles

Spontaneous Autoimmunity in Mice: Antibodies to Nucleoprotein in Strain A/J

George J. Friou 1 and Perry O. Teague 1

1 Departments of Medicine and Microbiology, University of Oklahoma Medical Center, Oklahoma City

An antibody to nucleoprotein, which appears to be an autoantibody, occurs in the ggr-globulin fraction of serum from mice of the A/J strain. This antibody combines with nucleoprotein of several species but not with calf thymus DNA. The frequency of its occurrence increases with age and is greater in females. Serums that contain the antibody produce typical lupus erythematosus cells in vitro.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)