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Science 21 February 1964:
Vol. 143. no. 3608, pp. 817 - 818
DOI: 10.1126/science.143.3608.817
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Articles

Inhibitory Postsynaptic Potentials in Grasshopper Muscle

P. N. R. Usherwood 1 and H. Grundfest 1

1 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 32

Hyperpolarizing inhibitory postsynaptic potentials have been discovered in fibers of the "jumping" muscle of the grasshopper. These potentials attenuate the depolarizing excitatory postsynaptic responses. They are enhanced during depolarization of the muscle fiber with applied current and are diminished and then reversed during hyperpolarization. The electrogenesisappears to be caused by chloride-activation. Gamma-aminobutyric acid activates the inhibitorysynaptic membrane and picrotoxin is an inactivator agent.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)