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Science 21 February 1964:
Vol. 143. no. 3608, pp. 815 - 816
DOI: 10.1126/science.143.3608.815
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Articles

Histocompatibility and Immunologic Competence in Renal Homotransplantation

Albert L. Rubin 1, Kurt H. Stenzel 1, Kurt Hirschhorn 2, and Fritz Bach 2

1 Rogosin Laboratories, Department of Medicine, New York Hospital-Cornell Medical Center, New York
2 Department of Medicine, New York University School of Medicine, New York

Cultures of peripheral lymphocytes may be used to assay histocompatibility. The lymphocytes from potential kidney recipients are cultured with those from potential donors and the percentage of large cells and mitoses stimulated is determined. The immunologic competence of cultured lymphocytes from recipients receiving immunosuppressive therapy is evaluated by determining their responsiveness to phytohemagglutinin. Suppression of response appears to be correlated with the absence of clinical signs of graft rejection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular Immune Competence of Breast Cancer Patients Receiving Radiotherapy.
A. B. Cosimi, F. H. Brunstetter, W. T. Kemmerer, and B. N. Miller (1973)
Arch Surg 107, 531-535
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One-Way Stimulation in Mixed Leukocyte Cultures.
F. H. Bach and N. K. Voynow (1966)
Science 153, 545-547
   Abstract »    PDF »
Tissue Culture Studies of the Human Lymphocyte: Experiments under controlled conditions provide new information on this cell's function and potentiality.
J. H. Robbins (1964)
Science 146, 1648-1654
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Genetic Studies on the Mixed Leukocyte Reaction.
B. Bain and L. Lowenstein (1964)
Science 145, 1315-1316
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Inhibition of Antibody Plaque Formation by Sensitized Lymphoid Cells: Rapid Indicator of Transplantation Immunity.
H. Friedman (1964)
Science 145, 607-609
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)