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Science 21 February 1964:
Vol. 143. no. 3608, pp. 807 - 808
DOI: 10.1126/science.143.3608.807
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Articles

Inhibition of Synthesis of the Cell Wall of Staphylococcus aureus by Cephalothin

Te-Wen Chang 1 and Louis Weinstein 1

1 Department of Medicine, Tufts University School of Medicine, and Pratt Clinie-New England Center Hospital, Boston, Massachusetts

Cephalothin, 7-(thiophene-2-acetamido)-cephalosporanic acid, suppresses synthesis of the cell of Staphylococcus aureus. Exposure to this agent led to a reduction in the degree of incorporation of carbon-14-lysine into the mucopeptide of the cell wall material and to an accumulation of N-acetyl glucosamine in the cell. The intensity of the lesions was comparable to that produced by penicillin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Cephalosporins: Microbiological, Chemical, and Pharmacological Properties and Use in Chemotherapy of Infection.
L. WEINSTEIN and K. KAPLAN (1970)
Ann Intern Med 72, 729-739
   Abstract »    PDF »
Intraocular Penetration of Cephaloridine: Observations in Experimental Animal and Human Eyes.
R. E. Records (1969)
Arch Ophthalmol 81, 331-335
   Abstract »    PDF »
Cross-Allergenicity of the Penicillins and the Cephalosporins.
M. H. Grieco (1967)
Arch Intern Med 119, 141-146
   Abstract »    PDF »
Molecular Mechanisms of Antibiotic Action.
W. CARTER and K. S. MCCARTY (1966)
Ann Intern Med 64, 1087-1113
   Abstract »    PDF »
Treatment of Infections in Man With Cephalothin.
L. Weinstein, K. Kaplan, and T.-W. Chang (1964)
JAMA 189, 829-834
   Abstract »    PDF »


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