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Science 14 February 1964:
Vol. 143. no. 3607, pp. 700 - 702
DOI: 10.1126/science.143.3607.700
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Articles

Heterotransplantation of the Kidney: Two Clinical Experiences

Keith Reemtsma 1, Brian H. McCracken 1, Jorgen U. Schlegel 1, and Maurice Pearl 1

1 Tulane University School of Medicine, New Orleans, Louisiana

The field of heterotransplantation is now being explored because of success with immunosuppressive measures in homotransplantation, and because of the scarcity of suitable human organs. Two patients in terminal uremia, maintained on dialysis, received heterotransplants from nonhuman primates. In the first case a renal heterotransplant from a rhesus monkey implanted in a 32-year old woman showed satisfactory immediate function but was removed after 10 days because of inadequate function. The second patient received a renal hetero transplant from a chimpanzee. A threatened rejection was reversed with immunosuppressive measures, but 2 months after transplantation the patient died of pneumonia. The transplanted kidneys showed no evidence of rejection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Xenografts: Review of the Literature and Current Status.
Council on Scientific Affairs (1985)
JAMA 254, 3353-3357
   Abstract »    PDF »
Detecting and Treating Early Renal Homotransplant Rejection.
S. L. Kountz, D. R. Laub, and R. Cohn (1965)
JAMA 191, 997-1001
   Abstract »    PDF »


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