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Science 14 February 1964:
Vol. 143. no. 3607, pp. 684 - 689
DOI: 10.1126/science.143.3607.684
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Articles

Actinomycin: Correlation of Structure and Function of Its Complexes with Purines and DNA

E. Reich 1

1 Rockfeller Institute, New York 21

Actinomycin inhibits strand separation of helical DNA at concentrations corresponding to those which inhibit DNA polymerase activity in vitro. This report proposes first that actinomycin affects DNA polymerase indirectly by way of the changed physical properties of the template and that it functions in the major groove of helical DNA; second, that RNA polymerase functioning in the minor groove is subject to direct steric inhibition by bound actinomycin; and third, that the reaction of actinomycin with free purines is unrelated to its reaction with DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Concerning the Stereochemistry of Actinomycin Binding to DNA: An Actinomycin-Deoxyguanosine Crystalline Complex.
H. M. Sobell, S. C. Jain, T. D. Sakore, G. Ponticello, and C. E. Nordman (1972)
Cold Spring Harb Symp Quant Biol 36, 263-270
   Abstract »    PDF »
Peptide Antibiotics.
M. Bodanszky and D. Perlman (1969)
Science 163, 352-358
   PDF »
Interaction of the Water-Soluble Carcinogen 4-Nitroquinoline N-Oxide with DNA.
M. F. Malkin and A. C. Zahalsky (1966)
Science 154, 1665-1667
   Abstract »    PDF »
Base Specificity in the Interaction of Polynucleotides with Antibiotic Drugs.
D. C. Ward, E. Reich, and I. H. Goldberg (1965)
Science 149, 1259-1263
   Abstract »    PDF »
Induction of Several Adaptive Enzymes by Actinomycin D.
F. Rosen, P. N. Raina, R. J. Milholland, and C. A. Nichol (1964)
Science 146, 661-663
   Abstract »    PDF »
Actinomycin D and the Response to Parathyroid Hormone.
H. Rasmussen, C. Arnaud, and C. Hawker (1964)
Science 144, 1019-1021
   Abstract »    PDF »


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