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Science 31 January 1964:
Vol. 143. no. 3605, pp. 479 - 480
DOI: 10.1126/science.143.3605.479
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Articles

Inhibition of Antibody Synthesis by L·Phenylalanine

Wayne L. Ryan 1 and Michael J. Carver 1

1 Department of Biochemistry, Creighton University School of Medicine and Nebraska Psychiatric Institute, University of Nebraska College of Medicine, Omaha

Antibody synthesis in response to the injection of diphtheria toxoid into rabbits and rats was used to study the effects of an excess of the amino acid L-phenylalanine on protein synthesis. Injections of phenylalanine produced a marked inhibition of antibody synthesis in both the rat and the rabbit. The dosage of phenylalanine used caused an increase over the normal concentration of phenylalanine in the plasma and spleen of rats, but did not cause a loss of weight or serum protein changes in the treated animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunologic Responsiveness in Phenylketonuria.
A. I. Terr, R. J. Allen, and N. A. Vanselow (1966)
JAMA 198, 1185-1188
   Abstract »    PDF »
Immune Responses in the Presence of Large Doses of Phenylalanine.
R. M. Appleman, R. G. Shorter, and G. A. Hallenbeck (1966)
JAMA 198, 1110-1112
   Abstract »    PDF »
Inhibition of the Immune Response by Phenylalanine: Application to Skin Transplantation.
W. L. Ryan (1965)
JAMA 191, 295-296
   Abstract »    PDF »


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