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Science 31 January 1964:
Vol. 143. no. 3605, pp. 477 - 478
DOI: 10.1126/science.143.3605.477
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Articles

Growth Inhibition of Sarcoma and Carcinoma Cells of Homozygous Origin

K. E. Hellström 1

1 Institute for Tumor Biology, Karolinska Institutet Medical School, Stockholm, Sweden

Three sarcomas and one carcinoma, originating in homozygous mice, were tested for growth in isologous animals and various semi-isologous F1 hybrids after inoculation of 103 to 105 cells. Findings indicated the existence of an "F1 hybrid effect" for sarcomas and carcinomas, as previously described for lymphomas and normal hematopoietic cells, there being a lower tumor frequency and a longer latency period in the hybrids than in isologous mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Abrogation of Allogeneic Inhibition by Cortisone.
K. E. Hellstrom, I. Hellstrom, and G. Haughton (1965)
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Hybrid Resistance to Parental Marrow Grafts: Association with the K Region of H-2.
G. Cudkowicz and J. H. Stimpfling (1964)
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Transplantation Antigens as Markers in Somatic Cell Genetics.
E. Klein (1964)
Cold Spring Harb Symp Quant Biol 29, 273-283
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